400 mg

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Trental (pentoxifylline) for Intermittent Claudication

I have had significant leg pain for a long time. This medication took about 1-2 months to start working, but then it was great. I could run on the treadmill at much faster speeds and for much longer - when previously I'd have cramps. Also, standing stationary used to be painful after 5-10 minutes - but this also improved. The only problem is that this medication can cause anxiety and insomnia since it is derived from xanthine (chemical cousin of caffeine). This is listed as a rare side effect on the drug insert, but I have heard it is more common from my doctor. I was actually given this for Peyronie's disease (off-label), but it didn't do much for that. It is supposed to inhibit TGF-beta (a cytokine) - decreasing scar tissue.

Class of medication

Miscellaneous coagulation modifiers

Other Doses

  • 400 mg
  • 400 mg

For Treatment

Intermittent Claudication


This trial published by Akriviadis et al in 2000 randomized 101 patients with severe alcoholic hepatitis at a single center to either pentoxifylline 400mg or placebo three times daily.
If you become pregnant while taking pentoxifylline, call your doctor.


  • If indicated, dosage of the antihypertensive agents should be reduced.
  • Pentoxifylline and vitamin E alone or important combination for preventing and treating side effects of radiation therapy and concomitant chemoradiotherapy.

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For the treatment of patients Trentilin intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs.

The treatment of overdosage should be symptomatic with particular attention to supporting the cardiovascular system. Jiang Xu, Zhou Zhou, Richard Parker, Bin Gao. Prolonged prothrombin times have been reported when pentoxifylline and oral anticoagulants have been used concomitantly. If indicated, dosage of the antihypertensive agents should be reduced.

If indicated, dosage of the antihypertensive agents should be reduced.

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