25 mg

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Benadryl (diphenhydramine) for Nausea/Vomiting

I take Methotrexate weekly 25mg and have found that taking Benadryl at dose and 12 and 24hrs after my weekly dose help reduce the nausea

Class of medication

Anticholinergic antiemetics

Other Doses

  • 25 mg
  • 50 mg/30 mL
  • 12.5 mg
  • 25 mg

For Treatment



Since diphenhydramine is used when needed, you may not be on a dosing schedule.


  • Benadryl, Sominex, Unisom, Nytol, and several others.
  • How to Get Rid of Bed Bugs.
  • These factors may affect how you should use this medication.

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